Why are COVID cases in India decreasing, despite the low double vaccination rate?
- Written by Rajib Dasgupta, Chairperson, Centre of Social Medicine and Community Health, Jawaharlal Nehru University
COVID continues to slow down in India. The festival season, which includes Durga Puja and Diwali where large groups of Indians gather, did not lead to a surge[1] in cases. Epidemiological modellers had earlier predicted[2] a third wave peaking during October and November.
Daily new cases have dropped from a peak[3] of more than 400,000 per day in May 2021 to currently below 10,000 cases a day[4].
And while antibody tests might give us a clue as to why, we can’t get complacent about vaccination rates.
Read more: Why couldn't India's health system cope during the second wave? Years of bad health policies[5]
Signals from recent antibody tests
In India, “serosurveys” have been regularly conducted since the pandemic began. This is where blood is tested from large numbers of people to check for the presence of COVID antibodies – the things our bodies make after being infected with COVID or receiving a COVID vaccine.
The fourth national survey[6] in July reported 67.6% of people across India had COVID antibodies present, providing them with a level of immunity against the virus. At that time 24.8% of people were immunised with a single dose of vaccine and 13% were fully vaccinated. This means a large proportion of those with antibodies had actually been infected with COVID.
Delhi reported 97% of people were positive for antibodies[7] in October, including 80% of children. Some 95.3% of those immunised with the Indian version of the Astrazeneca vaccine Covishield had developed antibodies, as did 93% of those who received India’s own vaccine Covaxin.
Read more: After early success, India's daily COVID infections have surpassed the US and Brazil. Why?[8]
The state of Haryana’s serosurvey in October[9] found antibodies in 76.3% of adults, upwards of 70% among children, and negligible difference between urban and rural populations.
Kerala had the lowest sero-prevalence of 44.4%[10] in the fourth national serosurvey in July, but in October it had risen to 82.6%[11] among the general population and 85.3% among residents of urban slums.
What does this mean for a “third wave” in India?
A third wave in India is an unlikely scenario with these high levels of antibodies, and vaccination levels continuing to rise.
It’s now recognised those who becoming naturally infected with COVID and recover before vaccination develop better immunity[12] than those who only have antibodies from vaccination. This is referred to as “hybrid immunity” – those with previous SARS-CoV-2 infection mount unusually potent immune responses[13] to the COVID vaccines.
The Centers for Disease Control[14] in the US notes that both the fully vaccinated individuals and previously infected groups have a low risk of subsequent infection for at least 6 months.
Read more: India's vaccine rollout is ignoring the many inequities in its society[15]
Results of the most recent national serosurvey[16] in India reflect the seroprevalence during the third week of June 2021; the Delta-led second wave had bottomed out at that time. Though about 30% of the population remained susceptible, subsequent serosurveys and an absence of any post-festival surge confirm continuing high levels of protection.
“Patchwork vaccination” areas, where there are pockets of low coverage of vaccination among areas with high levels of coverage, run the risk of small outbreaks, but are unlikely to be large enough to be of any major epidemiological concern.
With high seropositivity among adults, many of the new cases can now be expected among children, particularly with the reopening of educational institutions. But high levels of immunisation among teachers (upwards of 90%[17]) and the emerging evidence[18] that reopening schools has not been associated with significant increases in community transmission, are reassuring.
Experts predicted a surge after festivals like Diwali which didn’t eventuate. Idrees Mohammed/AAP
The WHO’s chief scientist said in late August[19] that India seems to be “entering some stage of endemicity”. Endemic[20] refers to the constant presence or usual prevalence of a disease in a population within a geographic area, where disease spread and rates are predictable.
Could a new variant, such as the Delta Plus subvariant first detected in India[21] in April 2021 threaten the current relative stability? While it has been said it might be about 10–15% more transmissible[22] than the Delta variant, the evidence from Europe[23] suggests it has not yet been able to establish any dominance over Delta.
Is vaccination on track?
Of India’s 1.4 billion people, 26.9%[24] are fully vaccinated and 54.9% have received at least one dose so far. But 35 million fewer women[25] have been vaccinated compared to men and independent analyses[26] show tribal and rural districts continue to lag.
Read more: Charging Indians for COVID vaccines is bad, letting vaccine producers charge what they like is unconscionable[27]
There are two current targets: achieving 90% coverage of the first dose by the end of November[28] and timely administration of the second dose. While the first is likely to be achieved, there are widespread reports of complacency regarding the second dose[29]. A campaign is underway[30] to encourage people to complete the schedule.
Delivering the billion plus doses[31] has convincingly demonstrated vaccine confidence. But convincing people to take a vaccine when for many it seems like the risk has passed is a difficult task. Prior infection-induced immunity protects against reinfection but this acquired immunity wanes over time. Hence the recommendation for COVID vaccination[32] for all eligible persons, including those who have been previously infected.
Districts with relatively low vaccine coverage require greater outreach efforts to reduce prevailing inequities. India’s immunisation program has demonstrated its strengths in polio eradication and measles-rubella elimination campaigns. We need to borrow some of those techniques to ensure all Indians are protected against COVID.
References
- ^ did not lead to a surge (www.aljazeera.com)
- ^ earlier predicted (timesofindia.indiatimes.com)
- ^ dropped from a peak (www.worldometers.info)
- ^ 10,000 cases a day (pib.gov.in)
- ^ Why couldn't India's health system cope during the second wave? Years of bad health policies (theconversation.com)
- ^ fourth national survey (twitter.com)
- ^ 97% of people were positive for antibodies (www.hindustantimes.com)
- ^ After early success, India's daily COVID infections have surpassed the US and Brazil. Why? (theconversation.com)
- ^ serosurvey in October (newsonair.gov.in)
- ^ lowest sero-prevalence of 44.4% (www.newindianexpress.com)
- ^ 82.6% (health.kerala.gov.in)
- ^ develop better immunity (www.nature.com)
- ^ unusually potent immune responses (www.science.org)
- ^ Centers for Disease Control (www.cdc.gov)
- ^ India's vaccine rollout is ignoring the many inequities in its society (theconversation.com)
- ^ Results of the most recent national serosurvey (www.newindianexpress.com)
- ^ upwards of 90% (www.telegraphindia.com)
- ^ emerging evidence (www.ecdc.europa.eu)
- ^ said in late August (www.bbc.com)
- ^ Endemic (www.cdc.gov)
- ^ first detected in India (gvn.org)
- ^ 10–15% more transmissible (onlinelibrary.wiley.com)
- ^ evidence from Europe (theconversation.com)
- ^ 26.9% (www.statista.com)
- ^ 35 million fewer women (dashboard.cowin.gov.in)
- ^ independent analyses (www.indiaspend.com)
- ^ Charging Indians for COVID vaccines is bad, letting vaccine producers charge what they like is unconscionable (theconversation.com)
- ^ end of November (www.hindustantimes.com)
- ^ complacency regarding the second dose (www.nytimes.com)
- ^ campaign is underway (www.news18.com)
- ^ billion plus doses (pib.gov.in)
- ^ recommendation for COVID vaccination (www.cdc.gov)
